Glycolytic-methylglyoxal pathway
نویسندگان
چکیده
منابع مشابه
Correlations between components of the glycolytic pathway.
1. The contents of dihydroxyacetone phosphate, fructose diphosphate, pyruvate and lactate and the activities of aldolase and lactate dehydrogenase in the liver, kidney, testis, skeletal muscle, blood cells, sarcoma and hepatoma of rats were measured. 2. Correlations were established between components of the glycolytic pathway as follows: activities of aldolase and lactate dehydrogenase; conten...
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Glycolysis (Embden-Meyerhof-Parnas pathway) is the most common sequence of reactions for the conversion of glucose-6-P into pyruvate in all domains of life. It generates ATP, reduced equivalents, and precursor metabolites for a multitude of essential cellular processes. During growth on substrates other then hexoses, essential glycolytic intermediates are synthesized via glyconeogenesis, revers...
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Protein glycation by methylglyoxal is a nonenzymatic post-translational modification whereby arginine and lysine side chains form a chemically heterogeneous group of advanced glycation end-products. Methylglyoxal-derived advanced glycation end-products are involved in pathologies such as diabetes and neurodegenerative diseases of the amyloid type. As methylglyoxal is produced nonenzymatically f...
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Methylglyoxal, a toxic metabolite synthesized in vivo during glycolysis, inhibits cell growth. One of the mechanisms protecting eukaryotic cells against its toxicity is the glyoxalase system, composed of glyoxalase I and II (glo1 and glo2), which converts methylglyoxal into d-lactic acid in the presence of glutathione. Here we have shown that the two principal oxidative stress response pathways...
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A sequence of 10 amino acids at the C-terminus region of methylglyoxal synthase from Escherichia coli (EMGS) provides an arginine, which plays a crucial role in forming a salt bridge with a proximal aspartate residue in the neighboring subunit, consequently transferring the allosteric signal between subunits. In order to verify the role of arginine, the gene encoding MGS from a thermophile spec...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1999
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.75.127